Premium
CD44+/CD133+ immunophenotype and matrix metalloproteinase‐9: Influence on prognosis in early‐stage oral squamous cell carcinoma
Author(s) -
Oliveira Lucinei R.,
Castilho–Fernandes Andrielle,
Oliveira–Costa João Paulo,
Soares Fernando A.,
Zucoloto Sérgio,
Ribeiro–Silva Alfredo
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23527
Subject(s) - cd44 , immunophenotyping , medicine , stage (stratigraphy) , immunohistochemistry , pathology , oncology , basal cell , cell , biology , flow cytometry , immunology , paleontology , genetics
Background The purpose of this study was to investigate the expression of CD44 and/or CD133 immunophenotypes and the associated effects of matrix metalloproteinase‐9 (MMP‐9) in early‐stage oral squamous cell carcinomas (SCC) to assess their influence on tumor prognosis. Methods The following data were derived from 150 patients: age, sex, primary anatomic site, smoking status, alcohol intake, recurrence, metastases, histological classification, treatment, disease‐free survival (DFS), and overall survival (OS). Immunohistochemical study of CD44, CD133, and MMP‐9 expression was performed on a tissue microarray of 150 paraffin blocks of oral SCCs. Results The predominant immunophenotype identified to exhibit a significant correlation with MMP‐9 was the CD44+/CD133+. Multivariate analyses identified a significant correlation of OS with surgical treatment and with CD44+/CD133+ immunophenotype. Conclusion This investigation demonstrated the prognostic importance of CD44/CD133 expression, which can help improve the prognostic value of surgical treatment for oral SCCs when diagnosed in early stages. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1718–1726, 2014