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Supraglottic immunoglobulin‐G4 related plasma cell granuloma: Case report and literature review
Author(s) -
Khoo Jeremy F.,
Batt Michael,
Stimpson Paul,
Safdar Adnan
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23519
Subject(s) - odynophagia , medicine , dysphagia , pharynx , larynx , granulomatous disease , granuloma , dermatology , rare disease , disease , pathology , surgery
Abstract Background Granuloma of the upper aerodigestive tract is a rare presentation of immunoglobulin‐G4 (IgG4)‐related disease. Since the disease process was defined in 2003, only 2 cases affecting the laryngopharynx have been reported in the literature. Methods and Results A 62‐year‐old white man presented with persistent productive cough of brown sputum, globus symptoms, dysphagia, odynophagia, dysphonia, otalgia, and general malaise over a period of 2 months. Investigations revealed IgG4‐positive plasma cell granuloma of the supraglottic region. This was successfully treated with oral corticosteroids. Conclusion Because IgG4 testing is not performed routinely, management recommendations have been poorly defined. We reviewed the literature and discuss herein the clinical characteristics, pathology, diagnosis, and management. The authors theorize that IgG4‐related disease involving the larynx and pharynx may be more common than suggested by the paucity of reported cases. © 2013 Wiley Periodicals, Inc. Head Neck 36: E57–E59, 2014