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Inherently poor survival of elderly patients with nasopharyngeal carcinoma
Author(s) -
Zhang Ye,
Yi JunLin,
Huang XiaoDong,
Xu GuoZhen,
Xiao JianPing,
Li SuYan,
Luo JingWei,
Zhang ShiPing,
Wang Kai,
Qu Yuan,
Gao Li
Publication year - 2015
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23497
Subject(s) - medicine , nasopharyngeal carcinoma , hazard ratio , charlson comorbidity index , comorbidity , confidence interval , radiation therapy , stage (stratigraphy) , multivariate analysis , medical record , carcinoma , head and neck cancer , anemia , gastroenterology , surgery , paleontology , biology
Background The purpose of this study was to determine the features of the elderly patient with nasopharyngeal carcinoma (NPC). Methods The medical records of 212 patients with NPC, aged ≥65 years, and receiving radiotherapy were retrospectively reviewed. Comorbidity was rated using the Charlson Comorbidity Index (CCI). Results Twenty‐four patients (11.3%) scored ≥3 and 188 patients (88.7%) scored <3 rated by CCI. The median actuarial irradiated dose of the nasopharynx was 72 Gy (range, 20–94 Gy) with 87.3% patients receiving >70 Gy. One hundred fifty‐four patients had stage III/IV disease. The actuarial local control, cancer‐specific survival (CSS), and overall survival (OS) rates at 5 years were 68.8%, 63.5%, and 47.0%, respectively. On multivariate analysis, stage (hazard ratio [HR], 1.489; 95% confidence interval [CI], 1.168–1.897; p = .001), the technique of radiotherapy (HR, 0.674; 95% CI, 0.476–0.953; p = .025), and anemia (HR, 3.081; 95% CI, 1.624–5.845; p = .001) were independent prognostic factors. Conclusion The elderly patients with NPC may inherently predict poor outcomes. © 2015 Wiley Periodicals, Inc. Head Neck 37: 771–776, 2015