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Use of local mitomycin C in enhancing laryngeal healing after laser cordotomy: A prospective controlled study
Author(s) -
Fawaz Samya A.,
Sabri Sabri M.,
Sweed Ahmed S.,
Hegazi Mona A.,
Riad Magdi A.
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23440
Subject(s) - medicine , mitomycin c , granulation tissue , surgery , anesthesia , wound healing
Background The purpose of this study was to investigate the role of intraoperative application of mitomycin C in prevention of glottic restenosis after posterior transverse CO 2 laser cordotomy (PTLC) for patients with post‐thyroidectomy bilateral vocal fold paralysis. Methods Twenty‐five patients with an impaired airway because of bilateral vocal fold paralysis were treated with PTLC. Patients were divided into groups: the mitomycin C group (13 patients) had PTLC and topical mitomycin C; and the control group (12 patients) had PTLC only. Results No patients in the mitomycin C group developed glottic granulation or laryngeal scarring, whereas 5 of 12 patients in the control group developed granulation ( p = .014) and 2 of 12 patients had laryngeal scarring ( p = .28). Ten of 13 patients in the mitomycin C group ended up with mild dyspnea with no limitation to normal everyday activities whereas only a third of the control group achieved this outcome ( p = .05). Conclusion The use of topical mitomycin C has been shown to decrease postoperative laryngeal granulation, scarring, restenosis, and the need for revision surgery. © 2014 Wiley Periodicals, Inc. Head Neck 36: 1248–1252, 2014