Premium
Continuous intra‐arterial chemotherapy for downstaging locally advanced oral commissure carcinoma
Author(s) -
Wu ChihFung,
Chang KaoPing,
Huang ChihJen,
Chen ChunMing,
Chen ChingYi,
Steve Lin ChenLung
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23408
Subject(s) - medicine , chemotherapy , methotrexate , basal cell , bolus (digestion) , surgery , survival rate , cancer , urology
Background The purpose of this study was to assess the usefulness, safety, and efficacy of intra‐arterial (IA) infusion chemotherapy for patients with locally advanced oral commissure cancer. Methods Twenty‐one patients with stages III and IV squamous cell carcinoma involving the mouth angle were recruited. Methotrexate (MTX; 50 mg/day) was continuously infused into the external carotid artery for a mean period of 8 days, followed by weekly IA bolus of 25 mg MTX for a mean period of 10 weeks. Results Thirteen patients (62%) achieved a complete response (CR) and 7 patients (33%) had a partial response (PR). At a median follow‐up of 69 months, the estimated 1‐year, 3‐year, and 5‐year survival rates of the patients with CR versus PR were 100% versus 57%, 92% versus 43%, and 80% versus 43%, respectively. Conclusion Our data demonstrate that continuous IA chemotherapy could achieve a competitive acceptable survival rate and improved locoregional control of advanced oral commissure cancer. © 2013 Wiley Periodicals, Inc. Head Neck 36: 1027–1033, 2014