Premium
Cervical metastases from squamous cell carcinoma of hard palate and maxillary alveolus: A retrospective study of 10 years
Author(s) -
Yang Zinan,
Deng Runzhi,
Sun Guowen,
Huang Xiaofeng,
Tang Enyi
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23398
Subject(s) - medicine , occult , hard palate , neck dissection , metastasis , incidence (geometry) , retrospective cohort study , soft palate , surgery , radiology , carcinoma , pathology , cancer , optics , physics , alternative medicine
Background The purpose of this study was to investigate the incidence of cervical metastasis in squamous cell carcinoma (SCC) of hard palate and maxillary alveolus and to define its impact factors. Methods We conducted a retrospective study of patients surgically treated for SCC of hard palate and maxillary alveolus from 2002 to 2011. In situ hybridization was performed to detect high‐risk human papillomavirus (HPV) infection. Results The incidences of cervical metastasis and occult metastasis were 17.2% (11/64) and 9.8% (5/51), respectively. The pT classification and vascular invasion were correlated with cervical metastasis. Occult metastatic risk was significantly higher among patients with pT4. Presence of positive nodes impaired prognosis significantly. Conclusion SCC of hard palate and maxillary alveolus has nonnegligible incidences of both overall and occult metastasis, which were highly associated with pT classification. We recommend routine, synchronous elective neck dissection for T4 lesions, whereas observation is an alternative for T1 to T3 lesions. © 2013 Wiley Periodicals, Inc. Head Neck 36: 969–975, 2014