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Tracheal reconstruction with asymmetrically porous polycaprolactone/pluronic F127 membranes
Author(s) -
Kwon Seong Keun,
Song JaeJun,
Cho Chang Gun,
Park SeokWon,
Kim Jin Rae,
Oh Se Heang,
Lee Jin Ho
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23343
Subject(s) - granulation tissue , tracheal stenosis , lumen (anatomy) , polycaprolactone , biomedical engineering , membrane , materials science , granulation , poloxamer , endoscopy , medicine , surgery , airway , chemistry , wound healing , composite material , polymer , biochemistry , copolymer
Background Congenital and acquired tracheal stenosis continues to be challenging problems. The purpose of this study was to evaluate the efficacy of an asymmetrically porous membrane (APM) to induce tracheal reconstruction by inhibition of granulation tissue growth into the tracheal lumen whereas minimizing graft failure. Methods The APM was fabricated with polycaprolactone (PCL) and pluronic F127 to have nano‐size pores at top side, whereas the bottom side had micro‐size pores. Fifteen rabbits underwent tracheal defect, which was then reconstructed with the APM. Rabbits were euthanized 1, 4, and 12 weeks postoperatively, and endoscopic, histologic, and radiologic evaluations were conducted. Results Endoscopy did not reveal granulation ingrowth into tracheal lumen. APM was well incorporated into the surrounding tissue on histologic evaluation. CT scans showed well maintained airways. Conclusion Off‐the‐shelf use of APM for tracheal reconstruction seems to be a promising strategy in the treatment of tracheal defects. © 2013 Wiley Periodicals, Inc. Head Neck 36 : 643–651, 2014