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Predictors of cervical lymph node metastasis in salivary gland cancer
Author(s) -
Ettl Tobias,
Gosau Martin,
Brockhoff Gero,
Schwarz–Furlan Stephan,
Agaimy Abbas,
Reichert Torsten E.,
Rohrmeier Christian,
Zenk Johannes,
Iro Heinrich
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23332
Subject(s) - pten , medicine , epidermal growth factor receptor , malignancy , tensin , oncology , lymph node , neck dissection , metastasis , salivary gland , pathology , salivary gland cancer , cancer , carcinoma ex pleomorphic adenoma , biology , pleomorphic adenoma , biochemistry , apoptosis , pi3k/akt/mtor pathway
Background This study compares clinicopathological parameters with novel molecular markers for predicting cervical lymph node metastasis in salivary gland cancer. Methods Three hundred sixteen salivary gland carcinomas were included in this study. Genomic epidermal growth factor receptor (EGFR), human epidermal growth factor receptor 2 (HER2), phosphatase and tensin homolog (PTEN), and hepatocyte growth factor receptor (MET) was determined by fluorescence in situ hybridization (FISH). Chi‐square tests, multivariate regression, and Kaplan–Meier survival analysis were used for statistics. Results Nodal staging determines long‐term survival. Clinicopathological parameters associated with positive neck nodes are advanced age ( p = .006), T3/T4 classification, histological high‐grade malignancy, and diagnosis of salivary duct carcinoma ( p < .001 each). Neck node metastases also correlate with copy number gain of EGFR ( p = .004) and HER2, aberration of MET, and deletion of PTEN ( p < .001 each). Multivariate analysis showed SDC ( p = .002) to be the strongest predictor of lymph node metastasis, followed by MET aberration ( p = .009), T3/T4 classification ( p = .017), PTEN deletion ( p = .042), and adenocarcinoma not otherwise specified (NOS; p = .047). Conclusion The histological subtype is crucial for decisions regarding neck dissection. New molecular parameters may also indicate elective treatment of the neck. © 2013 Wiley Periodicals, Inc. Head Neck 36 : 517–523, 2014