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Novel and simple prognostic index for nasal natural killer/T‐cell lymphoma
Author(s) -
Hanakawa Hiroyuki,
Orita Yorihisa,
Sato Yasuharu,
Takao Soshi,
Marunaka Hidenori,
Morishita Tokiwa,
Yamashita Yasuhiko,
Hori Yasutaka,
Domae Shuhei,
Inokuchi Ikuo,
Akagi Seiko,
Kondo Eisei,
Iwaki Noriko,
Motomiya Kana,
Okumura Hirokazu,
Yoshino Tadashi,
Nishizaki Kazunori
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23322
Subject(s) - medicine , nasal cavity , lymphoma , international prognostic index , lactate dehydrogenase , t cell lymphoma , gastroenterology , stage (stratigraphy) , natural killer t cell , oncology , immunology , t cell , diffuse large b cell lymphoma , surgery , immune system , biology , paleontology , biochemistry , enzyme
Background Few studies have investigated the prognostic factors for nasal natural killer (NK)/T‐cell lymphoma. Methods This was a retrospective multicenter clinical study. The clinical records of 36 patients with nasal NK/T‐cell lymphoma who had been first treated between 1996 and 2011 were collected from 12 hospitals. Results High serum levels of C‐reactive protein (≥1.0 mg/dL), lactate dehydrogenase (≥350 IU/L), and soluble interleukin‐2 receptor (sIL‐2R; ≥600 U/mL) were associated with worse prognosis. A prognostic score was devised by totaling the number of these 3 predictors: 0 or 1 = score 0; and 2 or 3 = score 1. As for tumor invasion, local invasion beyond the nasal cavity was associated with poor prognosis, and a prognostic score was devised as: tumor restricted to nasal cavity, yes = score 0; no = score 1. A novel prognostic index (NPI) was established based on these scores from 0 to 2. Disease‐specific survival rates at 5 years were: 90.0% for NPI = 0; 29.3% for NPI = 1; and 0.0% for NPI = 2. Conclusion Our NPI is valid for anticipating prognosis of nasal NK/T‐cell lymphoma. © 2013 Wiley Periodicals, Inc. Head Neck 36 : 551–556, 2014