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Oncologic outcomes of transoral laser microsurgery for radiorecurrent laryngeal carcinoma: A systematic review and meta‐analysis of English‐language literature
Author(s) -
Ramakrishnan Yujay,
Drinnan Mike,
Kwong Foon Ng Kee,
Grant David G.,
Mehanna Hisham,
Jones Terry,
Paleri Vinidh
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23291
Subject(s) - transoral laser microsurgery , medicine , meta analysis , confidence interval , laryngectomy , larynx , microsurgery , surgery , carcinoma , laryngeal neoplasm , medline , political science , law
Background The purpose of this systematic review and meta‐analysis was to assess the oncological and functional outcomes of transoral laser microsurgery (TLM) in radiorecurrent laryngeal cancer. Methods The review was performed using search strategies including Medline, Embase, Zetoc, conference proceedings, and a manual search. Pooled estimates of local control at 24 months, disease‐free survival (DFS), and overall survival (OS) rates were calculated. Results The pooled mean estimates were: local control rate at 24 months after first TLM ( n = 249), 56.9% (95% confidence interval [CI], 47.4–66.1); local control after repeat TLM ( n = 186), 63.8% (95% CI, 57.1–70.2); DFS ( n = 174), 70.9% (95% CI, 60.8–80); and OS ( n = 276), 74.8% (95% CI, 68.2–80.9). Pooled mean laryngeal preservation ( n = 286) was 72.3% (95% CI, 68.4–76.1). Conclusion TLM is oncologically sound in the salvage setting with high larynx‐preservation rate, but there is a trend toward inferior local control rates compared to open partial laryngectomy techniques. © 2013 Wiley Periodicals, Inc. Head Neck 36: 280–285, 2014