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Basaloid squamous cell carcinoma of the larynx: Analysis of 145 cases with comparison to conventional squamous cell carcinoma
Author(s) -
Fritsch Valerie A.,
Lentsch Eric J.
Publication year - 2014
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23286
Subject(s) - larynx , medicine , glottis , epidermoid carcinoma , head and neck , carcinoma , pathology , head and neck squamous cell carcinoma , basal cell , oncology , head and neck cancer , cancer , surgery
Background Basaloid squamous cell carcinoma (BSCC) is a rare subtype squamous cell carcinoma (SCC) that frequently occurs in the larynx. BSCC is generally considered an aggressive SCC variant; however, because of its rarity, most studies are underpowered to detect statistical differences in disease‐specific survival (DSS). Methods Using the Surveillance, Epidemiology, and End Results (SEER) database, we compared clinicopathologic data and DSS between patients with laryngeal BSCC and SCC. Results Patients with relative SCC, those with laryngeal BSCC, presented with more advanced local, regional, and distant disease ( p < .001). Patients with BSCC had worse DSS, regardless of stage, tumor location within the larynx (glottis/supraglottis; p < .001), or treatment received ( p ≤ .052). Conclusion Analysis of the largest laryngeal BSCC series to date ( n = 145) demonstrates that BSCC carries a worse prognosis than conventional SCC of the larynx. © 2013 Wiley Periodicals, Inc. Head Neck 36: 164–170, 2014