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Ewing sarcoma of the thyroid: Report of 2 cases and review of the literature
Author(s) -
Chan Jon M.,
Bilodeau Elizabeth,
Celin Scott,
Nikiforov Yuri,
Johnson Jonas T.
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23240
Subject(s) - sarcoma , thyroid , ewing's sarcoma , medicine , general surgery , pathology
Background Neuroendocrine tumors of the thyroid encompass a wide differential diagnosis. The most common is medullary thyroid carcinoma. One must consider other possibilities when a neuroendocrine thyroid tumor is calcitonin negative. We report 2 cases of Ewing sarcoma of the thyroid and discuss the differential diagnosis and workup of a calcitonin‐negative neuroendocrine tumor of the thyroid. Methods/Results This is a retrospective review of 2 patients diagnosed with Ewing sarcoma of the thyroid and a review of the literature. Conclusions Ewing sarcoma of the thyroid is an exceedingly rare diagnosis, but should be included in the differential diagnosis for a thyroidal neuroendocrine lesion (especially in the absence of calcitonin). The use and interpretation of immunohistochemistry (IHC) and fluorescent in situ hybridization are essential in making the correct diagnosis. © 2013 Wiley Periodicals, Inc. Head Neck , 35 : E346–E350, 2013