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Prognostic value of vascular endothelial growth factor in patients with head and neck cancer: A meta‐analysis
Author(s) -
Zang Jian,
Li Chen,
Zhao LiNa,
Shi Mei,
Zhou YongChun,
Wang JianHua,
Li Xin
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23156
Subject(s) - medicine , head and neck cancer , meta analysis , hazard ratio , vascular endothelial growth factor , confidence interval , oncology , subgroup analysis , cancer , vegf receptors
Background The correlation between vascular endothelial growth factor (VEGF) overexpression and the clinical outcome of head and neck cancer remains inconclusive. This meta‐analysis aimed to evaluate the prognostic value of VEGF in patients with head and neck cancer. Methods We searched Ovid MEDLINE, EMBASE and 2 Chinese science databases in order to enroll all eligible articles. Forty‐seven studies were included in this meta‐analysis. All results were evaluated by the random‐effects model. Results VEGF overexpression is significantly associated with worse overall survival (OS; hazard ratio [HR], 1.89; 95% confidence interval [CI], 1.61–2.22) and progression‐free survival (PFS; HR, 1.68; 95% CI, 1.33–2.12). Subgroup analysis reveals that VEGF overexpression is a significant poor predictor for nasopharyngeal cancer (HR, 1.66; 95% CI, 1.30–2.12) and salivary gland cancer (HR, 3.32; 95% CI, 1.61–6.84). Conclusion Our meta‐analysis supports that VEGF overexpression is an available poor predictor for patients with head and neck cancer. © 2012 Wiley Periodicals, Inc. Head Neck 35: 1507–1514, 2013