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Surgical margins in head and neck cancer: A contemporary review
Author(s) -
Hinni Michael L.,
Ferlito Alfio,
BrandweinGensler Margaret S.,
Takes Robert P.,
Silver Carl E.,
Westra William H.,
Seethala Raja R.,
Rodrigo Juan P.,
Corry June,
Bradford Carol R.,
Hunt Jennifer L.,
Strojan Primož,
Devaney Kenneth O.,
Gnepp Douglas R.,
Hartl Dana M.,
Kowalski Luiz P.,
Rinaldo Alessandra,
Barnes Leon
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23110
Subject(s) - margin (machine learning) , medicine , head and neck , head and neck squamous cell carcinoma , head and neck cancer , standardization , neck dissection , resection , basal cell , resection margin , dissection (medical) , surgery , general surgery , medical physics , carcinoma , radiation therapy , pathology , computer science , machine learning , operating system
Adequate resection margins are critical to the treatment decisions and prognosis of patients with head and neck squamous cell carcinoma (HNSCC). However, there are numerous controversies regarding reporting and interpretation of the status of resection margins. Fundamental issues relating to the basic definition of margin adequacy, uniform reporting standards for margins, optimal method of specimen dissection, and the role of intraoperative frozen section evaluation, all require further clarification and standardization. Future horizons for margin surveillance offer the possible use of novel methods such as “molecular margins” and contact microscopic endoscopy, However, the limitations of these approaches need to be understood. The goal of this review was to evaluate these issues to define a more rational, standardized approach for achieving resection margin adequacy for patients with HNSCC undergoing curative resection. © 2012 Wiley Periodicals, Inc. Head Neck, 2013