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Lessons learned from next‐generation sequencing in head and neck cancer
Author(s) -
Loyo Myriam,
Li Ryan J.,
Bettegowda Chetan,
Pickering Curtis R.,
Frederick Mitchell J.,
Myers Jeffrey N.,
Agrawal Nishant
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23100
Subject(s) - head and neck cancer , head and neck , cancer , medicine , computer science , surgery
Scientific innovation has enabled whole exome capture and massively parallel sequencing of cancer genomes. In head and neck cancer, next‐generation sequencing has granted us further understanding of the mutational spectrum of squamous cell carcinoma. As a result of these new technologies, frequently occurring mutations were identified in NOTCH1 , a gene that had not previously been implicated in head and neck cancer. The current review describes the most common mutations in head and neck cancer: TP53 , NOTCH1 , HRAS , PIK3CA , and CDKN2A . Emphasis is placed on the involved cellular pathways, clinical correlations, and potential therapeutic interventions. Additionally, the implications of human papillomavirus on mutation patterns are discussed. © 2012 Wiley Periodicals, Inc. Head Neck, 2013