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Primary intestinal‐like adenocarcinoma of major salivary glands: 2 instances of previously undocumented phenotype
Author(s) -
Gillenwater Ann M.,
Frank Steven J.,
Fatani Hanadi,
El–Naggar Adel K.
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23059
Subject(s) - medicine , adenocarcinoma , occult , pathology , immunohistochemistry , differential diagnosis , salivary gland , primary tumor , metastatic adenocarcinoma , gastroenterology , cancer , metastasis , alternative medicine
Background Primary intestinal‐like adenocarcinoma of the major salivary glands has not previously been reported. Methods The clinical and radiological findings of 2 patients with primary submandibular and sublingual tumors are presented. Histopathologic and immunohistochemical examinations of tumor sections were performed. Metastatic workup for distant occult primary was carried out. Results The light‐optic and the immunomarkers revealed intestinal‐like adenocarcinoma consistent with upper respiratory tract origin. Metastatic workup of both patients was negative for primary gastro‐intestinal primary. Conclusion Primary intestinal‐like adenocarcinoma can develop in major salivary glands and should be considered in the differential diagnosis. © 2012 Wiley Periodicals, Inc. Head Neck, 2012