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Prognostic factors in head and neck squamous cell carcinoma: Comparison of CHAID decision trees technology and cox analysis
Author(s) -
Avilés–Jurado Francesc Xavier,
León Xavier
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23058
Subject(s) - chaid , head and neck squamous cell carcinoma , medicine , proportional hazards model , oncology , head and neck , survival analysis , basal cell , decision tree , head and neck cancer , surgery , artificial intelligence , radiation therapy , computer science
Background The purpose of this study was to compare the risk factors obtained from a classical statistical method (Cox proportional hazards model) and the results obtained with classification trees (Chi‐square Automatic Interaction Detection [CHAID] model) in head and neck squamous cell carcinoma (HNSCC). Methods We conducted a retrospective study of 3373 patients with HNSCC and a follow‐up longer than 2 years. Results The most decisive variable classified by CHAID was T category. N classification was an important prognostic factor in the Cox analysis, but this was not considered in CHAID except in T2 and supraglottic T3. CHAID also indicated that women with oral cavity T3/T4 to N0 tumors had poorer prognosis (28%) than men (58.5%; p value < .001). In oropharynx location, men had lower survival than women (41% vs 72%; p value < .001). Conclusions The main benefit of CHAID analysis is that it identifies a relatively small number of patients with a singular behavior, which is more discriminatory for an optimal diagnosis and treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2012