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Identification of novel target proteins in sebaceous gland carcinoma
Author(s) -
Erovic Boban M.,
Al Habeeb Ayman,
Harris Luke,
Goldstein David P.,
Kim Dae,
Ghazarian Danny,
Irish Jonathan C.
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.23021
Subject(s) - epidermal growth factor receptor , cancer research , angiogenesis , biology , carcinogenesis , wnt signaling pathway , sebaceous gland , cancer , endocrinology , receptor , signal transduction , microbiology and biotechnology , biochemistry , genetics
Background The aim of this study was to identify new target proteins in sebaceous gland carcinoma. Methods A tissue microarray containing 115 core biopsies was constructed and stained for proteins involved in carcinogenesis, angiogenesis, inflammation, and cell‐to‐cell contact. Two investigators independently determined protein expression of all antibodies. Results Vascular endothelial growth factor receptor 2 (VEGFR‐2), platelet‐derived growth factor receptor alpha and beta (PDGFR‐α/‐β), epidermal growth factor receptor (EGFR), cyclooxygenase 1 and 2 (Cox‐1/‐2), myeloid cell leukemia sequence 1 (Mcl‐1), matrix metalloproteinase 1 (MMP‐1), CD9, Bmi‐1, 14‐3‐3σ, glutathione S‐transferase pi (Gstπ), and members of the sonic hedgehog (SHH), AKT, and WNT pathways were significantly overexpressed in sebaceous gland carcinomas. Conclusions We have demonstrated for the first time that proteins related to angiogenesis, inflammation, and cell proliferation are overexpressed in sebaceous gland carcinomas. These proteins may hold promise as novel therapeutic targets for the treatment of sebaceous gland carcinoma. © 2012 Wiley Periodicals, Inc. Head Neck, 2013