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Comparison of total laryngectomy with surgical (cricohyoidopexy) and nonsurgical organ‐preservation modalities in advanced laryngeal squamous cell carcinomas: A multicenter retrospective analysis
Author(s) -
Bussu Francesco,
Paludetti Gaetano,
Almadori Giovanni,
De Virgilio Armando,
Galli Jacopo,
Miccichè Francesco,
Tombolini Mario,
Rizzo Davide,
Gallo Andrea,
Giglia Veronica,
Greco Antonio,
Valentini Vincenzo,
De Vincentiis Marco
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22994
Subject(s) - medicine , laryngectomy , larynx , surgery , radiation therapy , chemoradiotherapy , basal cell , laryngeal neoplasm , survival rate , quality of life (healthcare) , nursing
Background Functional outcome and quality of life (QOL) have become relevant endpoints in the field of laryngeal oncology, leading to the emergence of organ‐preserving strategies. Methods The medical records of 166 patients with advanced (stages III and IV) laryngeal squamous cell carcinoma (SCC) who were treated with a total laryngectomy, radiochemotherapy, or cricohyoidopexy (CHP) were reviewed. Results In the whole series, no statistically significant differences among the 3 treatment arms with respect to the overall survival (OS) and disease‐specific survival (DSS) rates were observed. The organ‐preservation rate was 45% for radiotherapy and 76.7% for CHP ( p = .0002). Among the cT4a cases, a longer survival was observed for the patients treated with total laryngectomy (3 yr‐OS = 78% vs 68% for CHP and 54% for radiochemotherapy, p = .031). Conclusions In advanced laryngeal SCC, CHP shows survival rates comparable to those of radiochemotherapy and a higher larynx‐preservation rate, although it may not replace radiochemotherapy because it can be recommended only in selected cases. © 2012 Wiley Periodicals, Inc. Head Neck, 2013