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Tumor angiogenesis: Role in locally aggressive biological behavior of ameloblastoma and keratocystic odontogenic tumor
Author(s) -
Gadbail Amol Ramchandra,
Mankar Gadbail Mugdha P.,
Hande Alka,
Chaudhary Minal S.,
Gondivkar Shailesh M.,
Korde Sheetal,
Gawande Madhuri N.,
Patil Swati,
Tekade Satyjitraje,
Sharma Aparna
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22960
Subject(s) - ameloblastoma , keratocystic odontogenic tumor , dentigerous cyst , angiogenesis , medicine , pathology , immunohistochemistry , oral mucosa , odontogenic tumor , odontogenic , dentistry , cancer research , maxilla
Abstract Background The purpose of this study was to assess and compare angiogenesis in ameloblastoma, keratocystic odontogenic tumors, dentigerous cysts, and normal oral mucosa. Methods Angiogenesis was assessed in 28 ameloblastoma–36 keratocystic odontogenic tumors, 28 dentigerous cysts, and 19 normal oral mucosa by measuring the mean vascular density (MVD), total vascular area (TVA) and mean vascular area (MVA). Immunohistochemistry was carried out by using CD105. Results The nonsignificant difference of MVD was noted between ameloblastoma and keratocystic odontogenic tumors ( p = .174). TVA and MVA were significantly higher in ameloblastoma than keratocystic odontogenic tumors, normal oral mucosa, and dentigerous cysts ( p < .001). MVD, TVA, and MVA were significantly higher in keratocystic odontogenic tumors than normal oral mucosa and dentigerous cysts ( p < .001). Conclusion The results suggest that tumor angiogenesis may play an important role in locally invasive aggressive biologic behavior of ameloblastoma and keratocystic odontogenic tumor. The angiogenesis could be a potent target for developing antiangiogenic therapeutic strategies, particularly in recurrent cases of odontogenic tumors. Head Neck, 2013