BMP‐2 immobilized on nanocrystalline diamond–coated titanium screws; demonstration of osteoinductive properties in irradiated bone | Zendy

Kloss Frank R. | Zendy; Singh Sarvpreet | Zendy; Hächl Oliver | Zendy; Rentenberger Julia | Zendy; Auberger Thomas | Zendy; Kraft Anna | Zendy; Klima Guenther | Zendy; Mitterlechner Thomas | Zendy; SteinmüllerNethl Doris | Zendy; Lethaus Bernd | Zendy; Rasse Michael | Zendy; Lepperdinger Guenter | Zendy; Gassner Robert | Zendy

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BMP‐2 immobilized on nanocrystalline diamond–coated titanium screws; demonstration of osteoinductive properties in irradiated bone

Author(s) -

Kloss Frank R.,

Singh Sarvpreet,

Hächl Oliver,

Rentenberger Julia,

Auberger Thomas,

Kraft Anna,

Klima Guenther,

Mitterlechner Thomas,

SteinmüllerNethl Doris,

Lethaus Bernd,

Rasse Michael,

Lepperdinger Guenter,

Gassner Robert

Publication year - 2013

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.22958

Subject(s) - osseointegration , osteosynthesis , titanium , mesenchymal stem cell , irradiation , dentistry , bone morphogenetic protein , nanocrystalline material , implant , bone healing , biomedical engineering , chemistry , materials science , medicine , surgery , nanotechnology , pathology , metallurgy , biochemistry , physics , nuclear physics , gene

Background Irradiation results in impaired bone healing. Thus, osteosynthesis procedures are afflicted with increased failure rates. To improve osseointegration bone morphogenetic protein‐2 (BMP‐2) immobilized on nanocrystalline diamond (NCD)–coated implant surfaces might be 1 solution. Methods By 4 weeks after irradiation of pig's mandible with a dose of 60 Gy a fracture was accomplished. Osteosynthesis was performed either with titanium osteosynthesis screws or NCD‐coated screws with immobilized BMP‐2. Nonirradiated animals served as control. After 1, 2, 4, and 8 weeks screws were evaluated histologically. Bone biopsies were gained to extract mesenchymal stem or precursor cells (MSCs). Results MSCs after irradiation demonstrated a behavior comparable to that of unirradiated cells. Consequently, immobilized BMP‐2 resulted in an initial increased bone contact ratio ( p = .014) but demonstrated no sustainable effect compared with osseointegration in nonirradiated bone ( p = .08). Conclusion Immobilized BMP‐2 demonstrates an osteoinductive effect in irradiated bone. MSCs as effector cells possess protective mechanisms to overcome the destructive effect of irradiation. © 2012 Wiley Periodicals, Inc. Head Neck, 2013

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