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Primary neuroendocrine neoplasms of the larynx. A series of 4 cases reported and a review of the literature
Author(s) -
Angouridakis Nikolaos,
Goudakos John,
Karayannopoulou Georgia,
Triaridis Stefanos,
Nikolaou Angelos,
Markou Konstantinos
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22955
Subject(s) - larynx , medicine , neuroendocrine tumors , head and neck , pathology , medical record , radiology , surgery
Background Neuroendocrine tumors are rare neoplasms arising from neural and epithelial origin. Methods and Results The case records of 4 patients with the diagnosis of neuroendocrine laryngeal tumor were retrospectively reviewed. In this analysis of our medical records, we describe a series of 4 men with neuroendocrine laryngeal tumors treated in our department since 1994, including the first extremely aggressive and lethal laryngeal paraganglioma reported in the English‐language literature. We also discuss the classification, the macro and microscopical characteristics, clinical and pathologic findings, and treatment of these neoplasms. Conclusion Although neuroendocrine laryngeal tumors account for approximately 1% of all neoplasms in the larynx, its majority represents very aggressive tumors showing a capacity for metastasis and portending poor outcome. © 2012 Wiley Periodicals, Inc. Head Neck, 2012