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t(3;8) as the sole chromosomal abnormality in a myoepithelial carcinoma ex pleomorphic adenoma: A putative progression event
Author(s) -
Bell Diana,
N. Myers Jeffrey,
Rao Pulivarthi H.,
ElNaggar Adel K.
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22926
Subject(s) - carcinoma ex pleomorphic adenoma , pleomorphic adenoma , myoepithelial cell , chromosomal translocation , carcinoma , malignant transformation , pathology , adenoma , biology , cancer research , salivary gland , medicine , genetics , gene , immunohistochemistry
Background Carcinoma ex pleomorphic adenoma (Ca ex‐PA) is defined as a carcinoma arising from a primary (de novo) or recurrent benign pleomorphic adenoma (PA). Methods We present a parotid myoepithelial carcinoma ex pleomorphic adenoma in a 38‐year‐old man with a t(3;8)(p21;q13) as the only chromosomal alteration by cytogenetic and spectral karyotypic analysis (SKY). Results The finding of this translocation in a subset of PA and in the present case suggests a critical role for this event in the malignant transformation of PA. Conclusions Collectively, both the cytogenetic and the molecular studies suggest the concept that PA lacking alterations pursue a benign behavior, whereas those with the t(3;8) translocation may progress to carcinoma. © 2012 Wiley Periodicals, Inc. Head Neck, 2012