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Cyclooxygenase‐2 expression and clinical parameters in laryngeal squamous cell carcinoma, vocal fold nodule, and laryngeal atypical hyperplasia
Author(s) -
Sayar Cağdaş,
Sayar Hamide,
Özdemir Süleyman,
Selçuk Tahsin,
Görgülü Orhan,
Akbaş Yücel,
Kemal Olgun Mustafa
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22911
Subject(s) - pathology , medicine , atypical hyperplasia , staining , carcinoma , hyperplasia , laryngeal neoplasm , nodule (geology) , immunohistochemistry , carcinogenesis , cyclooxygenase , cancer , biology , enzyme , paleontology , biochemistry
Background The diagnostic role of cyclooxygenase‐2 (COX‐2) expression in laryngeal atypical hyperplasia, vocal fold nodule, and laryngeal squamous cell carcinoma was examined. Methods Specimens obtained from patients diagnosed with vocal fold nodule ( n = 35), atypical hyperplasia ( n = 35), laryngeal squamous cell carcinoma ( n = 35), and clinical parameters were evaluated retrospectively. Results Although no staining was observed in patients with vocal fold nodules, staining was noted in laryngeal atypical hyperplasia and squamous cell carcinoma. The percentage of COX‐2 staining was the highest in the carcinoma group. Conclusion It was determined that COX‐2 staining was significantly associated with laryngeal squamous cell carcinoma. It should be noted that overexpression of COX‐2, a potentially important factor in the evolution of carcinogenesis in precancerous lesions, might be an indicator of the development of carcinoma. © 2012 Wiley Periodicals, Inc. Head Neck, 2013