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Preoperative prediction of papillary thyroid carcinoma prognosis with the assistance of computerized morphometry of cytology samples obtained by fine‐needle aspiration: Preliminary report
Author(s) -
Shih Shyang–Rong,
Chang Yi–Cheng,
Li Hung–Yuan,
Liau Jau–Yu,
Lee Chia–Yen,
Chen Chung–Ming,
Chang Tien–Chun
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22909
Subject(s) - medicine , papillary carcinoma , cytology , fine needle aspiration cytology , radiology , fine needle aspiration , thyroid carcinoma , carcinoma , thyroid , pathology , general surgery , biopsy
Background The purpose of this study was to analyze the relationship between cytologic features, clinical features, and recurrence of papillary thyroid cancer (PTC). We hoped to predict prognosis preoperatively. Methods We retrospectively studied cytologic features by using computerized morphometry and clinical data of 118 patients with usual‐type PTC without initial metastasis, including 34 patients with cancer recurrence in 10 years after surgery and 84 patients who did not have recurrence for more than 10 years after surgery. Another 24 patients were recruited for validation. Results Multivariate logistic analysis indicated that nucleus‐to‐cell ratio, variation of nuclear area, tumor size, and patient age were significantly related to recurrence. Cox regression analysis showed that hazard ratios were 3.34, 1.53, 1.77, and 2.6, respectively. Conclusion Cytologic features of PTC analyzed with computerized morphometry significantly correlated with recurrence. It helped to predict prognosis preoperatively and may be helpful for planning further treatment. © 2012 Wiley Periodicals, Inc. Head Neck, 2013