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Prognostic value of 18 F‐FDG PET/CT in patients with squamous cell carcinoma of the tonsil: Comparisons of volume‐based metabolic parameters
Author(s) -
Moon Seung Hwan,
Choi Joon Young,
Lee Hwan Joo,
Son YoungIk,
Baek ChungHwan,
Ahn Yong Chan,
Park Keunchil,
Lee KyungHan,
Kim ByungTae
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22904
Subject(s) - medicine , nuclear medicine , standardized uptake value , hazard ratio , positron emission tomography , tonsil , proportional hazards model , confidence interval , fluorodeoxyglucose , head and neck cancer , oncology , cancer , pathology
Background The prognostic significance of volume‐based metabolic parameters measured by 18 F‐fluorodeoxyglucose positron emission tomography/CT ( 18 F‐FDG PET/CT) is not established. We evaluated the prognostic value of metabolic parameters in patients with squamous cell carcinoma (SCC) of the tonsil. Methods We enrolled a total of 69 patients with SCC of the tonsil who underwent pretreatment 18 F‐FDG PET/CT. We measured maximum standardized uptake value (SUV max ), metabolic tumor volume (MTV), total lesion glycolysis (TLG), and asymmetry indices (of SUV max , MTV, and TLG). The prognostic significance of these parameters and clinical variables was assessed by Cox proportional hazards regression analysis. Results Multivariate analyses with adjustments for age, sex, and American Joint Committee on Cancer stage showed that only TLG (hazard ratio = 1.020, 95% confidence interval 1.003–1.037, p = .023) was an independent predictive factor associated with decreased overall survival. Conclusion TLG is a significant independent metabolic prognostic factor for overall survival in patients with SCC of the tonsil. © 2012 Wiley Periodicals, Inc. Head Neck, 2013