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Prevalence of human papillomavirus in oropharyngeal and nonoropharyngeal head and neck cancer—systematic review and meta‐analysis of trends by time and region
Author(s) -
Mehanna Hisham,
Beech Tom,
Nicholson Tom,
ElHariry Iman,
McConkey Christopher,
Paleri Vinidh,
Roberts Sally
Publication year - 2013
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.22015
Subject(s) - medicine , confidence interval , human papillomavirus , meta analysis , head and neck cancer , logistic regression , head and neck , cancer , demography , oncology , surgery , sociology
Background Little information has been reported on regional and time trends of human papillomavirus (HPV) prevalence rates of oropharyngeal cancer (OPC) and non‐OPC. Methods The study consisted of a systematic review and meta‐analysis using random effects logistic regression models. Results Overall HPV prevalence in OPC (47.7%; 95% confidence interval [CI], 42.9–52.5%) increased significantly over time: from 40.5% (95% CI, 35.1–46.1) before 2000, to 64.3% (95% CI, 56.7–71.3) between 2000 and 2004, and 72.2% (95% CI, 52.9–85.7) between 2005 and 2009 ( p < .001). Prevalence increased significantly in North America and Europe, and the significant gap between them that existed before 2000 (50.7% vs 35.3%, respectively, p = .008) has now disappeared (69.7% vs 73.1%, respectively, p = .8). Prevalence in non‐OPC (21.8%; 95% CI, 18.9–25.1%) has not increased over time ( p = .97) Conclusions The sharp increase in the proportion of HPV‐positive OPC over the last decade has occurred at a faster rate in Europe compared with that in North America. In contrast, the relatively low prevalence of HPV in non‐OPC remains unchanged. © 2012 Wiley Periodicals, Inc. Head Neck, 2013