Phase I study of weekly docetaxel and cisplatin arterial infusion for recurrent head and neck cancer | Zendy

Nakamura Tatsuya | Zendy; Fuwa Nobukazu | Zendy; Takayama Kanako | Zendy; Inokuchi Haruo | Zendy; Tomoda Takuya | Zendy; Takada Akinori | Zendy; Makita Chiyoko | Zendy; Shiomi Miho | Zendy; Yokouchi Jun–ichi | Zendy; Watanabe Kazuo | Zendy

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Phase I study of weekly docetaxel and cisplatin arterial infusion for recurrent head and neck cancer

Author(s) -

Nakamura Tatsuya,

Fuwa Nobukazu,

Takayama Kanako,

Inokuchi Haruo,

Tomoda Takuya,

Takada Akinori,

Makita Chiyoko,

Shiomi Miho,

Yokouchi Jun–ichi,

Watanabe Kazuo

Publication year - 2012

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.21983

Subject(s) - docetaxel , medicine , leukopenia , head and neck cancer , cisplatin , regimen , toxicity , chemotherapy , cancer , limiting , anesthesia , oncology , urology , mechanical engineering , engineering

Background We planned a phase I study of weekly arterial infusion of docetaxel and cisplatin via a superficial temporal artery for recurrent head and neck cancer to determine the optimal dose. Methods The dose of cisplatin was fixed and the dose of docetaxel was escalated from 8 mg/m 2 , with an increase of 2 mg/m 2 per step, to identify the maximum tolerated dose (MTD). In total, 4 courses of weekly chemotherapy were administered. Results Twelve patients were recruited to this trial. The MTD of docetaxel was 14 mg/m 2 . At this dose level, dose‐limiting toxicity was observed in 2 of 3 patients. One patient experienced grade 3 leukopenia, while the other experienced grade 3 leukopenia. Myelosuppression was the dose‐limiting toxicity for this regimen. Conclusion The recommended dose for weekly arterial infusion of docetaxel was identified as 12 mg/m 2 combined with weekly cisplatin at 40 mg/m 2 , with 4 courses of each. © 2011 Wiley Periodicals, Inc. Head Neck , 2011

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