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Thyroid gland involvement in advanced laryngeal cancer: Association with clinical and pathologic characteristics
Author(s) -
Hilly Ohad,
Raz Raanan,
Vaisbuch Yona,
Strenov Yulia,
Segal Karl,
Koren Rumelia,
Shvero Jacob
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21972
Subject(s) - laryngectomy , medicine , thyroid , larynx , thyroidectomy , thyroid cancer , cancer , pathology , surgery
Abstract Background Indications for thyroidectomy during laryngectomy are controversial. We examined whether clinicopathologic features can predict thyroid gland involvement, and the prognostic effect of thyroid gland involvement in patients undergoing total laryngectomy. Methods The study set out to review preoperative assessment, operation findings, pathologic findings, and follow‐up data. Results Thyroid gland involvement was found in 11 of 53 patients (21%) undergoing total laryngectomy and thyroidectomy. Preoperative work‐up failed to predict thyroid gland involvement. Thyroid gland involvement was associated with salvage procedures ( p = .025), paratracheal metastases ( p = .003), and poor overall survival (hazard ratio = 2.74, p = .008). Conclusions Thyroid gland involvement in patients undergoing total laryngectomy is frequent and is associated with poor prognosis. Preoperative assessment failed to predict thyroid gland involvement. We believe that thyroidectomy should be considered in cases with paratracheal lymphatic spread irrespective of tumor location within the larynx. © 2011 Wiley Periodicals, Inc. Head Neck , 2011