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mTHPC mediated interstitial photodynamic therapy of recurrent nonmetastatic base of tongue cancers: Development of a new method
Author(s) -
Karakullukcu Baris,
Nyst Heike J.,
van Veen Robert L.,
Hoebers Frank J. P.,
Hamming–Vrieze Olga,
Witjes Max J. H.,
de Visscher Sebastiaan A. H. J.,
Burlage Fred R.,
Levendag Peter C.,
Sterenborg Henricus J. C. M.,
Tan I. Bing
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21969
Subject(s) - medicine , brachytherapy , photodynamic therapy , tongue , head and neck cancer , surgery , radiation therapy , fistula , cancer , radiology , pathology , chemistry , organic chemistry
Background Interstitial photodynamic therapy (iPDT) can be an option in the management of locally recurrent base of tongue cancer after (chemo)radiation treatment. The purpose of the current study was to develop a technique to implant light sources into the tumor tissue. Methods Twenty patients with previously irradiated locally recurrent base of tongue cancers who were not candidates for salvage surgery or reirradiation or refused these therapies were included in this study. The treatment planning was done on MRI. The light sources were implanted using modified brachytherapy techniques. Results The iPDT could be conducted in all patients without short‐term complications. At 6 months, 9 patients had complete response with 4 patients still free of disease (46–80 months). Long‐term complications included pharyngocutaneous fistula in 6 patients, serious bleeding in 1 patient, and cutaneous metastasis in 2 patients. Conclusion The initial results are encouraging. There is room for improvement to control the destructive potential of iPDT through planning and monitoring tools. © 2012 Wiley Periodicals, Inc. Head Neck, 2012