Premium
Role of FDG‐PET as a biological marker for predicting the hypoxic status of tongue cancer
Author(s) -
Han Myung Woul,
Lee Hee Jin,
Cho Kyung–Ja,
Kim Jae Seung,
Roh Jong–Lyel,
Choi Seung–Ho,
Nam Soon Yuhl,
Kim Sang Yoon
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21945
Subject(s) - tumor hypoxia , medicine , hypoxia (environmental) , tongue , immunohistochemistry , positron emission tomography , biomarker , erythropoietin receptor , cancer , head and neck cancer , oncology , erythropoietin , pathology , nuclear medicine , radiation therapy , biology , chemistry , oxygen , biochemistry , organic chemistry
Abstract Background To determine whether 2‐[ 18 F]fluoro‐2‐deoxy‐D‐glucose positron emission tomography (FDG‐PET) could serve as a useful technique predicting tumor hypoxia and prognosis in tongue cancer, we assessed the relationship between FDG uptake and the levels of hypoxia‐related markers. Methods Tumor uptake of FDG in 33 patients with T2 tongue cancer was assessed by measuring maximum standardized uptake values (SUVmax). Expression of hypoxia‐inducible factor (HIF)‐1α, carbonic anhydrase (CA)‐9, glucose transporter (GLUT)‐1, and erythropoietin receptor (EPOR), was determined by immunohistochemical staining. Correlation between SUVmax and the expression of hypoxia‐related markers was assessed and multivariate analysis was performed to determine what parameters affected clinical outcomes. Results We observed strong correlations between SUVmax and expression of HIF‐1α ( p < .05), CA‐9 ( p < .01), and GLUT‐1 ( p < .01). SUVmax, HIF‐1α expression, and tumor grade were significant independent predictors of disease‐free survival (DFS). Conclusion SUVmax may be a good noninvasive biomarker for prediction of hypoxic status and prognosis of patients with T2 tongue cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2011