Premium
Expression of cancer‐testis antigens MAGE‐A4 and MAGE‐C1 in oral squamous cell carcinoma
Author(s) -
Montoro José Raphael de Moura Campos,
Mamede Rui Celso Martins,
Neder Serafini Luciano,
Saggioro Fabiano Pinto,
Figueiredo David Livingstone Alves,
Silva Wilson Araújo da,
Jungbluth Achim A.,
Spagnoli Giulio Cesare,
Zago Marco Antônio
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21880
Subject(s) - immunohistochemistry , antigen , cancer , exact test , basal cell , medicine , head and neck squamous cell carcinoma , antibody , carcinoma , oncology , cancer research , gene , head and neck cancer , pathology , biology , immunology , biochemistry
Abstract Background Tumor markers are genes or their products expressed exclusively or preferentially in tumor cells and cancer‐testis antigens (CTAs) form a group of genes with a typical expression pattern expressed in a variety of malignant neoplasms. CTAs are considered potential targets for cancer vaccines. It is possible that the CTA MAGE‐A4 (melanoma antigen) and MAGE‐C1 are expressed in carcinoma of the oral cavity and are related with survival. Methods This study involved immunohistochemical analysis of 23 patients with oral squamous cell carcinoma (SCC) and was carried out using antibodies for MAGE‐A4 and MAGE‐C1 . Fisher's exact test and log‐rank test were used to evaluate the results. Results The expression of the MAGE‐A4 and MAGE‐C1 were 56.5% and 47.8% without statistical difference in studied variables and survival. Conclusion The expression of at least 1 CTA was present in 78.3% of the patients, however, without correlation with clinicopathologic variables and survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2012