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Gene–environment interactions of novel variants associated with head and neck cancer
Author(s) -
Liang Caihua,
Marsit Carmen J.,
Houseman E. Andres,
Butler Rondi,
Nelson Heather H.,
McClean Michael D.,
Kelsey Karl T.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21867
Subject(s) - head and neck cancer , genetics , head and neck , gene , computational biology , biology , cancer , head (geology) , medicine , paleontology , surgery
Background A genome‐wide association study for upper aerodigestive tract cancers identified 19 candidate single‐nucleotide polymorphisms (SNPs). We used these SNPs to investigate the potential gene–gene and gene–environment interactions in head and neck squamous cell carcinoma (HNSCC) risk. Methods The 19 variants were genotyped using Taq man assays among 575 cases and 676 controls in our population‐based case–control study. Results A restricted cubic spline model suggested both ADH1B and HEL308 modified the association between smoking pack‐years and HNSCC. Classification and regression tree analysis demonstrated a higher‐order interaction between smoking status, ADH1B , FLJ13089 , and FLJ35784 in HNSCC risk. Compared with ever smokers carrying ADH1B T/C+T/T genotypes, smokers carrying ADH1B C/C genotype and FLJ13089 A/G+A/A genotypes had the highest risk of HNSCC (odds ratio = 1.84). Conclusions Our results suggest that the risk associated with these variants may be specifically important among specific exposure groups. © 2011 Wiley Periodicals, Inc. Head Neck, 2012