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Genetic profile of second primary tumors and recurrences in head and neck squamous cell carcinomas
Author(s) -
Gutiérrez Virginia Franco,
Marcos César Álvarez,
Llorente José Luis,
Guervós Marta Alonso,
Iglesias Francisco Domínguez,
Tamargo Luis Argüelles,
Hermsen Mario
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21824
Subject(s) - multiplex ligation dependent probe amplification , primary tumor , medicine , head and neck squamous cell carcinoma , head and neck , basal cell , primary (astronomy) , oncology , pathology , head and neck cancer , gene , biology , cancer , surgery , metastasis , genetics , physics , astronomy , exon
Background Second primary tumors and recurrences are an important problem in patients with head and neck squamous cell carcinoma. The purpose of this study was to determine the genetic changes in tumor samples to improve knowledge of tumor progression. Methods Copy number changes of 37 genes were analyzed by multiplex ligation‐dependent probe amplification (MLPA) in 36 primary tumors and their corresponding 21 second primary tumors and 15 recurrences. Results CCND1 and EMS1 amplifications and gain of BCL2L1 were the most common genetic alterations in the primary tumor, second primary tumor, and recurrence samples. Gains of ERBB2 and PTPN1 were associated with recurrences. Conclusion Specific genetic profiles for each group have been found. Similarities between primary tumor and second primary tumor and dissimilarity between primary tumor and recurrence suggest that clinicopathological criteria do not always accurately differentiate these entities. Genetic profiling may aid in the diagnosis and prognosis of these difficult cases. © 2011 Wiley Periodicals, Inc. Head Neck , 2011