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Salivary protein and solCD44 levels as a potential screening tool for early detection of head and neck squamous cell carcinoma
Author(s) -
Franzmann Elizabeth J.,
Reategui Erika P.,
Pereira Lutecia H. Mateus,
Pedroso Felipe,
Joseph Debbie,
Allen Glenn O.,
Hamilton Kara,
Reis Isildinha,
Duncan Robert,
Goodwin W. Jarrard,
Hu Jennifer J.,
Lokeshwar Vinata B.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21810
Subject(s) - head and neck squamous cell carcinoma , confidence interval , logistic regression , medicine , odds ratio , oncology , area under the curve , stage (stratigraphy) , basal cell , cd44 , head and neck cancer , cell , cancer , biology , paleontology , genetics
Background Head and neck squamous cell carcinoma (HNSCC) is a devastating disease usually diagnosed at a late stage when cure rates are 40%. We examined a simple and inexpensive molecular tool that may aid HNSCC detection. Methods Building on prior findings that total protein levels are elevated in 102 HNSCC cases versus 84 control subjects, we further analyzed these levels with respect to important risk and demographic variables and compared the results to soluble CD44 (solCD44). Using multivariate adaptive regression splines (MARSs)‐logit modeling and logistic regression, we determined whether total protein, solCD44, or the combination best identifies HNSCC. Results Combined higher levels of solCD44 and protein were significantly associated with HNSCC (odds ratio [OR] = 24.90; 95% confidence interval [CI], 9.04–68.57; area under the curve [AUC] = 0.786). A model including protein plus solCD44 resulted in a better area (AUC 0.796) than either marker alone. Conclusion Oral rinse levels of solCD44 and protein seem to hold promise for detection of HNSCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012