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Identification of a cut‐off for the macis score to predict the prognosis of differentiated thyroid carcinoma in children and young adults
Author(s) -
Jang Hye Won,
Lee Ji In,
Kim Hee Kyung,
Oh Young Lyun,
Choi Yoon–La,
Jin Dong–Kyu,
Kim Jung–Han,
Chung Jae Hoon,
Kim Sun Wook
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21808
Subject(s) - medicine , thyroid carcinoma , receiver operating characteristic , young adult , oncology , medical record , scoring system , distant metastasis , carcinoma , metastasis , thyroid , cancer
Abstract Background The metastases, age at diagnosis, completeness of resection, invasion, size of the tumor (MACIS) scoring system was developed to predict disease‐specific survival in patients with differentiated thyroid carcinoma (DTC), mainly for adults, with a cut‐off score of 6. The purpose of this study was to evaluate its ability to predict prognosis of DTC in children and young adults. Methods The medical records of 66 children and young adult (<21 years old) patients with DTC were reviewed retrospectively. Receiver operating characteristic (ROC) analysis was performed to determine the cut‐off for predicting poor prognosis. Results Extrathyroidal invasion and regional lymph node metastasis were noted in 64% each, and distant metastases were found in 8%. The optimal cut‐off for the MACIS score for poor prognosis was 4 (93% sensitivity, 67% specificity). The overall 10‐year recurrence‐free survival was better in patients with MACIS score <4 than score ≥4 ( p < .05). Conclusion A MACIS score of more than 4 was associated with a poor prognosis in children and young adult patients with DTC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012