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Utility of daily image guidance with intensity‐modulated radiotherapy for tumors of the base of skull
Author(s) -
Chen Allen M.,
Cheng Suzan,
Farwell D. Gregory,
Luu Quang,
Donald Paul J.,
Boggan James,
Franklin Stephen,
Purdy James A.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21805
Subject(s) - skull , radiation therapy , base (topology) , intensity (physics) , medicine , radiology , computer science , medical physics , physics , anatomy , mathematics , optics , mathematical analysis
Background This study was carried out to report our experience using intensity‐modulated radiotherapy (IMRT) with daily image‐guided radiotherapy (IGRT) for tumors involving the base of skull. Methods In all, 100 patients were prospectively treated with IMRT to a median dose of 64 Gy (range, 45–70 Gy). Daily helical megavoltage computed tomography (MVCT) scans were obtained as part of an IGRT registration protocol for patient alignment. Results The 2‐year local‐regional control was 91%. A total of 3295 daily MVCT scans were obtained. The mean shift to account for interfraction motion was 1.18 ± 1.75 mm, 1.81 ± 1.34 mm, and 1.33 ± 1.19 mm for the medial–lateral (ML), superior–inferior (SI), and anterior–posterior (AP) directions, respectively. Pretreatment shifts of >3 mm occurred in 10%, 26%, and 18%, in the ML, SI, and AP directions, respectively. Conclusions The feasibility and efficacy of daily IGRT as a complement to IMRT for skull base were demonstrated. © 2011 Wiley Periodicals, Inc. Head Neck, 2011