Premium
Head and neck paragangliomas: Report of 175 patients (1989–2010)
Author(s) -
Papaspyrou Konstantinos,
Mewes Torsten,
Rossmann Heidi,
Fottner Christian,
SchneiderRaetzke Brigitte,
Bartsch Oliver,
Schreckenberger Mathias,
Lackner Karl J.,
Amedee Ronald G.,
Mann Wolf J.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21790
Subject(s) - sdhd , sdhb , paraganglioma , medicine , thyroid carcinoma , head and neck , malignancy , thyroid , mutation , gene mutation , oncology , pathology , germline mutation , gene , surgery , biology , genetics
Background Attention of the otorhinolaryngologist needs to be drawn to the versatile aspects of head and neck paragangliomas (PGLs). Methods This study is a retrospective, nonrandomized clinical study of all 175 individuals with PGLs treated in our department between 1989 and 2010. A genetic analysis was performed on 86 patients. Results The 175 patients presented 224 head and neck PGLs as well as 2 thyroid papillary carcinomas. Genetic analysis resulted in 1 patient positive for a von Hippel‐Lindau (VHL) gene mutation and 34 for succinate dehydrogenase (SDH) gene mutations (22 SDHD, 7 SDHC, and 5 SDHB), 12 of the latter carrying a novel mutation. Thirty‐three patients (18.9%) had multiple PGLs and 11 patients (6.3%) had a malignant paraganglioma. SDH‐mutation carriers had multiple tumors in 64.7% and malignant paragangliomas in 20.6%. Conclusions Multifocal occurrence, potential malignancy, genetic aspects, possible coincidence of thyroid carcinoma, and hormone production have to be considered in patients with head and neck PGLs. © 2011 Wiley Periodicals, Inc. Head Neck, 2012
Accelerating Research
Robert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom
Address
John Eccles HouseRobert Robinson Avenue,
Oxford Science Park, Oxford
OX4 4GP, United Kingdom