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Head and neck paragangliomas: Report of 175 patients (1989–2010)
Author(s) -
Papaspyrou Konstantinos,
Mewes Torsten,
Rossmann Heidi,
Fottner Christian,
SchneiderRaetzke Brigitte,
Bartsch Oliver,
Schreckenberger Mathias,
Lackner Karl J.,
Amedee Ronald G.,
Mann Wolf J.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21790
Subject(s) - sdhd , sdhb , paraganglioma , medicine , thyroid carcinoma , head and neck , malignancy , thyroid , mutation , gene mutation , oncology , pathology , germline mutation , gene , surgery , biology , genetics
Background Attention of the otorhinolaryngologist needs to be drawn to the versatile aspects of head and neck paragangliomas (PGLs). Methods This study is a retrospective, nonrandomized clinical study of all 175 individuals with PGLs treated in our department between 1989 and 2010. A genetic analysis was performed on 86 patients. Results The 175 patients presented 224 head and neck PGLs as well as 2 thyroid papillary carcinomas. Genetic analysis resulted in 1 patient positive for a von Hippel‐Lindau (VHL) gene mutation and 34 for succinate dehydrogenase (SDH) gene mutations (22 SDHD, 7 SDHC, and 5 SDHB), 12 of the latter carrying a novel mutation. Thirty‐three patients (18.9%) had multiple PGLs and 11 patients (6.3%) had a malignant paraganglioma. SDH‐mutation carriers had multiple tumors in 64.7% and malignant paragangliomas in 20.6%. Conclusions Multifocal occurrence, potential malignancy, genetic aspects, possible coincidence of thyroid carcinoma, and hormone production have to be considered in patients with head and neck PGLs. © 2011 Wiley Periodicals, Inc. Head Neck, 2012