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Prognostic value of fluorine‐18 fluorodeoxyglucose positron‐emission tomography imaging in patients with head and neck squamous cell carcinoma
Author(s) -
Querellou Solène,
Abgral Ronan,
Le Roux PierreYves,
Nowak Emmanuel,
Valette Gérald,
Potard Gaël,
Le DucPennec Alexandra,
Cavarec MarieBéatrice,
Marianovski Rémi,
Salaün PierreYves
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21765
Subject(s) - medicine , standardized uptake value , fluorodeoxyglucose , positron emission tomography , basal cell , head and neck squamous cell carcinoma , multivariate analysis , head and neck , head and neck cancer , carcinoma , nuclear medicine , cancer , radiology , oncology , surgery
Background High tumor uptake of fluorodeoxyglucose (FDG) is associated with an unfavorable outcome in patients with cancer. We evaluated FDG uptake as a prognostic factor in patients with head and neck squamous cell carcinoma. Methods Maximum standardized uptake values (SUVmax) of tumor, liver, and pulmonary artery were recorded. Ratios of SUVmax from tumor to liver (T/L) and from tumor to pulmonary artery (T/PA) were calculated for each patient. Clinical data, tumor, and SUVmax ratios were compared with disease‐free survival (DFS) and overall survival (OS). Results Eighty‐nine patients were included: 48 presented a local recurrent disease or distant metastases and 42 died. For both DFS and OS, tumor SUVmax value of 7 was the best cutoff value and 4 and 5 for T/L and T/PA ratios. Multivariate analysis confirmed the independent prognostic value of these 3 thresholds for DFS and OS. Conclusions FDG uptake has a significant and independent relationship with recurrence and survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2012