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Role of prophylactic thyroidectomy in RET 790 familial medullary thyroid carcinoma
Author(s) -
Bihan Hélène,
Baudin Eric,
Meas Taly,
Leboulleux Sophie,
Al Ghuzlan Abir,
Hannoteaux Véronique,
Travagli JeanPaul,
Valleur Patrice,
Guillausseau PierreJean,
Cohen Régis
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21763
Subject(s) - medicine , thyroidectomy , asymptomatic , calcitonin , thyroid carcinoma , medullary cavity , medullary carcinoma , dissection (medical) , lymph node , neck dissection , carcinoma , thyroid , surgery , gastroenterology
Background We describe a family harboring RET 790 mutation and review the role of prophylactic thyroidectomy for medullary thyroid carcinoma. Methods We evaluated in detail both clinical and biological follow‐up and reviewed literature reports. Results Among 86 family members, 15 of 22 members screened harbored the 790 mutation. Abnormal calcitonin levels were found in 8/15. Total thyroidectomy with lymph node dissection cured the 5 operated patients (range, 45–76 years). Tumor staging was pT1N0M0. Among 10 carriers who did not undergo surgery, 3 patients had abnormal calcitonin levels. For the others, calcitonin levels remained <30 pg/mL. Two asymptomatic carriers were older than 70 years. Four subjects were lost to follow‐up. Conclusions In RET codon 790 mutations families, a case‐by‐case decision instead of systematic prophylactic thyroidectomy should be discussed. Difficulties of follow‐up should be taken into account and represent the main challenge. © 2011 Wiley Periodicals, Inc. Head Neck, 2012