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Matched cohort analysis of the effect of pretreatment positron emission tomography on clinical outcomes of patients with head and neck cancer treated with definitive chemoradiotherapy
Author(s) -
Fried David,
Khandani Amir,
Shores Carol,
Weissler Mark,
Hayes Neil,
Hackman Trevor,
Rosenman Julian,
Chera Bhishamjit S.
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21745
Subject(s) - medicine , head and neck squamous cell carcinoma , positron emission tomography , chemoradiotherapy , head and neck cancer , cohort , retrospective cohort study , clinical endpoint , oncology , cancer , radiology , nuclear medicine , multivariate analysis , clinical trial
Background Pretreatment positron emission tomography (PET) has been shown to be useful for patients with head and neck squamous cell carcinoma (HNSCC) after definitive chemoradiotherapy (CRT). Methods We conducted a retrospective analysis of a matched cohort of 116 patients with HNSCC that underwent CRT treatment at our institution. Pretreatment PET was performed in 58 patients and omitted in the other 58 patients. The 2 cohorts were matched for T classification, N classification, primary site, and smoking history. Kaplan–Meier 2‐year estimates of local control (LC), regional control (RC), freedom from distant metastasis (FFDM), cause‐specific survival (CSS), and overall survival (OS) were compared with log‐rank tests. Results There were no differences between the 2 cohorts for 2‐year endpoints of LC, RC, FFDM, CSS, and OS. On multivariate analysis pretreatment PET imaging did not influence any endpoint. Conclusions PET imaging before definitive CRT may not significantly improve outcomes in patients with HNSCC. © 2011 Wiley Periodicals, Inc. Head Neck, 2012