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Identification of the peripheral blood levels of interleukin‐12, interleukin‐10, and transforming growth factor‐β in patients with laryngeal squamous cell carcinoma
Author(s) -
Günaydın Rıza Önder,
Kesikli Sacit Altuğ,
Kansu Emin,
Hoşal Ali Şefik
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21738
Subject(s) - stage (stratigraphy) , transforming growth factor , medicine , interleukin , basal cell , carcinoma , metastasis , peripheral blood , gastroenterology , oncology , pathology , cytokine , cancer , biology , paleontology
Background The aim of this study was to investigate the biology of laryngeal squamous cell carcinoma (SCC) to develop effective novel treatment modalities. Methods Serum concentrations of interleukin (IL)‐10, IL‐12, and transforming growth factor‐β (TGF‐β) were evaluated in 50 patients with laryngeal SCC and 15 controls. Results were compared according to tumor‐node‐metastasis (TNM) classification criteria. Results IL‐12 and TGF‐β levels were not different between the early‐ and late‐stage patients and controls. Tumor classification or nodal involvement was not associated with IL‐12 and TGF‐β levels. Patients with laryngeal SCC had significantly more detectable serum IL‐10 levels than those of controls, given that IL‐10 could be detected in only 1 early‐stage and 9 late‐stage patients, but not in the control group ( p = .003). IL‐10 was increasingly detectable with advanced T classification ( p = .009) and nodal involvement ( p = .008). Conclusions Serum IL‐12 or TGF‐β levels were not affected with disease activity and classification; however, serum IL‐10 levels were correlated with both parameters. © 2011 Wiley Periodicals, Inc. Head Neck, 2012