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High‐risk human papillomavirus and cervical lymph node metastasis in patients with oropharyngeal cancer
Author(s) -
Joo YoungHoon,
Jung ChanKwon,
Sun DongIl,
Park JunOok,
Cho KwangJae,
Kim MinSik
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21697
Subject(s) - medicine , oncology , human papillomavirus , lymph node metastasis , lymph node , metastasis , cervical cancer , head and neck cancer , cancer
Background The purpose of this study was to determine the role of high‐risk human papillomavirus (HPV) in lymph node metastasis and the depth of invasion in oropharyngeal cancer. Methods The study included patients with 90 oral carcinomas and 66 oropharyngeal carcinomas. High‐risk HPV in situ hybridization was performed to detect HPV infection. Results The positive rate of high‐risk HPV in situ hybridization was 15.4% (24 of 156). There was a significant difference in the fraction of positive high‐risk HPV between oral (6.7%) and oropharyngeal (27.3%) cancers ( p < .000). Significant correlations were found between positive high‐risk HPV and cervical lymph node metastasis, tumor depth of invasion in patients with oropharyngeal cancer ( p = .002, p = .016, respectively). There was a statistically significant association between high‐risk HPV positivity and the disease‐specific survival in patients with oropharyngeal cancer ( p = .035). Conclusion High‐risk HPV infection was significantly related to cervical lymph node metastasis and depth of invasion in patients with oropharyngeal cancer. © 2011 Wiley Periodicals, Inc. Head Neck, 2012