Premium
Hh‐Gli signaling pathway activity in oral and oropharyngeal squamous cell carcinoma
Author(s) -
Leovic Dinko,
Sabol Maja,
Ozretic Petar,
Musani Vesna,
Car Diana,
Marjanovic Ksenija,
Zubcic Vedran,
Sabol Ivan,
Sikora Miroslav,
Grce Magdalena,
GlavasObrovac Ljubica,
Levanat Sonja
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21696
Subject(s) - gli1 , ptch1 , hedgehog , hedgehog signaling pathway , cancer research , patched , immunohistochemistry , stroma , carcinogenesis , medicine , biology , pathology , signal transduction , cancer , microbiology and biotechnology
Background The aim of this study was to examine the role of Hh‐Gli signaling in oral and oropharyngeal squamous cell carcinoma (SCC). The role of this signaling pathway in SCC formation has not yet been elucidated. Methods Sixty‐four tissue and blood samples were collected from 60 patients with SCC, all tobacco and alcohol users. An additional six buccal mucosa tissue samples were collected from nonsmokers and nondrinkers as control tissue. Results Hedgehog‐Gli pathway components were associated with clinical and pathologic features. Broders' grade and N stage were associated with higher Ptch1 and lower Gli1 expression. Tumor stage was negatively associated with Smo expression, and tumor size was positively associated with p16 expression. Ptch1 and Shh were frequently detected in the surrounding stroma. Ptch1 was found to be correlated with p16 expression, as well as with survivin expression. Conclusions The signaling pathway is activated in SCC and inducible in vitro by Shh protein. © 2011 Wiley Periodicals, Inc. Head Neck, 2012