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Pretreatment nutritional status and locoregional failure of patients with head and neck cancer undergoing definitive concurrent chemoradiation therapy
Author(s) -
Platek Mary E.,
Reid Mary E.,
Wilding Gregory E.,
Jaggernauth Wainwright,
Rigual Nestor R.,
Hicks Wesley L.,
Popat Saurin R.,
Warren Graham W.,
Sullivan Maureen,
Thorstad Wade L.,
Khan Mohamed K.,
Loree Thom R.,
Singh Anurag K.
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21640
Subject(s) - medicine , head and neck cancer , chemoradiotherapy , univariate analysis , radiation therapy , multivariate analysis , oncology , cancer , retrospective cohort study , surgery
Background This study was carried out to determine if markers of nutritional status predict for locoregional failure following intensity‐modulated radiation therapy (IMRT) with concurrent chemoradiotherapy (CCRT) for squamous cell carcinoma of the head and neck (SCCHN). Methods We performed a retrospective chart review of 78 patients with SCCHN who received definitive CCRT. We compared patient factors, tumor characteristics, and nutritional status indicators between patients with and without locoregional failure. Results Fifteen of 78 patients (19%) experienced locoregional failure. Median follow‐up for live patients was 38 months. On univariate analysis, pretreatment percentage of ideal body weight (%IBW) ( p < .01), pretreatment hemoglobin ( p = .04), and treatment duration ( p < .01) were significant predictors of failure. On multivariate analysis, pretreatment %IBW ( p = .04) and treatment time ( p < .01) remained statistically significant. Conclusions Although treatment time is an accepted risk factor for failure, differences in outcome for patients with head and neck cancer undergoing definitive CCRT based on pretreatment %IBW should be examined further. © 2010 Wiley Periodicals, Inc. Head Neck, 2011