Premium
Surgical management of radiation‐induced temporal lobe necrosis in patients with nasopharyngeal carcinoma: Report of 14 cases
Author(s) -
Mou Yonggao,
Sai Ke,
Wang Zhenning,
Zhang Xiangheng,
Lu Yanchun,
Wei Danian,
Yang Qunying,
Chen Zhongping
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21639
Subject(s) - nasopharyngeal carcinoma , temporal lobe , medicine , trismus , radiation therapy , necrosis , complication , surgery , radiology , skull , carcinoma , pathology , epilepsy , psychiatry
Background Radiation‐induced temporal lobe necrosis is a rare and serious late complication in irradiated patients with nasopharyngeal carcinoma (NPC). Treatment of radiation‐induced temporal lobe necrosis with surgery has been seldom thoroughly investigated. Methods We retrospectively analyzed the clinical data of 14 patients with radiation‐induced temporal lobe necrosis treated with surgical intervention. Results Radiation‐induced temporal lobe necrosis presented as obvious cystic formation or as heterogeneous enhanced nodule on MRI. Among 3 patients with 18 F‐fluorodeoxyglucose ( 18 F‐FDG) PET‐CT scan, increased uptake of 18 F‐FDG was observed in 2 cases. Four patients were anesthestized nasotracheally and 1 was through tracheostomy during surgery because of other radiation complications, including trismus and skull base osteoradionecrosis. The temporal approach was applied in all cases, with the removal of bone flap in 11 patients. During follow‐up, 1 patient died of exhaustion. Conclusions Surgery benefits selected patients with NPC with radiation‐induced temporal lobe necrosis. The goals of surgery are to relieve the increased intracranial pressure and to establish the accurate diagnosis. © 2010 Wiley Periodicals, Inc. Head Neck, 2010