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Surgical salvage nasopharyngectomy for recurrent nasopharyngeal carcinoma: A multivariate analysis of prognostic factors
Author(s) -
Vlantis Alexander C.,
Chan Hing Sang,
Tong Michael C. F.,
Yu Brian K. H.,
Kam Michael K. M.,
van Hasselt C. Andrew
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21585
Subject(s) - medicine , nasopharyngeal carcinoma , multivariate analysis , hazard ratio , chemoradiotherapy , univariate analysis , oncology , salvage surgery , salvage therapy , radiation therapy , surgery , chemotherapy , confidence interval
Background The purpose of this study was to identify independent prognostic factors that influenced local relapse‐free survival (LRFS) and overall survival (OS) of patients who underwent salvage surgery for residual or recurrent nasopharyngeal carcinoma (NPC). Methods Ninety‐seven patients who had been treated with radiotherapy or chemoradiotherapy for NPC underwent a nasopharyngectomy for a residual or recurrent local tumor between November 1987 and June 2007. The subsequent minimum follow‐up was 2 years. Univariate and multivariate analyses were performed to identify prognostic factors for LRFS and OS. Results The 5‐year LRFS and OS was 46.7% and 51.9%, respectively. On multivariate analysis for LRFS and OS, respectively, recurrent regional disease (hazard ratio [HR], 3.245; p = .008) and (HR, 4.990; p = .001), and positive surgical margins (HR, 5.963; p = .000), and (HR, 4.912; p = .000) were independent prognostic factors. Conclusion In patients undergoing surgical salvage nasopharyngectomy for residual or recurrent NPC, positive surgical margins have an independent negative influence on LRFS and OS. © 2010 Wiley Periodicals, Inc. Head Neck, 2011