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Outcome of patients treated surgically for lymph node metastases from cutaneous squamous cell carcinoma of the head and neck
Author(s) -
Givi Babak,
Andersen Peter E.,
Diggs Brian S.,
Wax Mark K.,
Gross Neil D.
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21574
Subject(s) - medicine , hazard ratio , lymph node , radiation therapy , oncology , multivariate analysis , confidence interval , proportional hazards model , cervical lymph nodes , head and neck squamous cell carcinoma , neck dissection , head and neck cancer , surgery , carcinoma , metastasis , cancer
Background There is a paucity of outcomes data for patients with lymph node metastasis from cutaneous squamous cell carcinoma of head and neck (SCCHN). Methods Patients from a tertiary care center with cutaneous SCCHN metastatic to parotid and or cervical lymph nodes were identified. Data were abstracted and analyzed using COX multivariate analysis. Results Fifty‐one patients (47 men, and 4 women) with a median age of 73 years were identified. Eight patients (16%) had recurrent disease and 11 (22%) were immunosuppressed. Forty patients (71%) received adjuvant radiation therapy. Median overall survival was 23 months (range, 3–148 months). Recurrent disease was associated with higher risk of death (hazard ratio [HR], 2.7; 95% confidence interval [CI] 1.1–6.9) and radiation therapy with reduced risk (HR, 0.18; 95% CI, 0.06–0.54). Conclusion Lymph node metastases from cutaneous SCCHN is associated with poor survival. © 2011 Wiley Periodicals, Inc. Head Neck, 2011