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Long–term follow‐up of 44 patients with adenocarcinoma of the nasal cavity and sinuses primarily treated with endoscopic resection followed by radiotherapy
Author(s) -
Van Gerven Laura,
Jorissen Mark,
Nuyts Sandra,
Hermans Robert,
Vander Poorten Vincent
Publication year - 2011
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21556
Subject(s) - medicine , radiation therapy , surgery , adenocarcinoma , stage (stratigraphy) , paranasal sinuses , cohort , cancer , paleontology , biology
Background Endoscopic resection followed by radiotherapy as primary treatment for adenocarcinoma of the sinuses is emerging as an alternative to open resection. Methods A total of 44 patients primarily treated by an endoscopic approach followed by radiotherapy from 1992 to 2004 seen at our ENT‐Department were analyzed for outcome and prognostic factors. Results Median follow‐up was 61 months. Median follow‐up of the patients alive at the end of the follow‐up period was 100 months. For the 5‐year follow‐up, the overall survival, disease‐specific survival, and recurrence‐free survival were 63% (±7% SE), 82% (±6), and 60% (±8%), respectively. The overall survival, disease‐specific survival, and recurrence‐free survival after 100 months of follow‐up were 53% (±8%), 72% (±9%), and 54% (±9%), respectively. Four factors significantly influenced the disease‐specific survival. Conclusion This study of a homogeneous cohort of patients with sinonasal adenocarcinoma treated by endoscopic resection and radiotherapy confirms that endoscopic resection is a valid alternative to open resection. © 2010 Wiley Periodicals, Inc. Head Neck, 2011