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Long‐term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high‐dose intravenous methotrexate
Author(s) -
Fakhry Carole,
Bajaj Gopal,
Aygun Nafi,
Westra William,
Gillison Maura
Publication year - 2012
Publication title -
head and neck
Language(s) - English
Resource type - Journals
SCImago Journal Rank - 1.012
H-Index - 127
eISSN - 1097-0347
pISSN - 1043-3074
DOI - 10.1002/hed.21516
Subject(s) - medicine , nasopharyngeal carcinoma , methotrexate , asymptomatic , oncology , carcinoma , surgery , radiation therapy
Background. Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis. Methods and Results. We present a case report of a patient with nasopharyngeal carcinoma who was treated with high‐dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later. Conclusions. Systemic high‐dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement. © 2010 Wiley Periodicals, Inc. Head Neck, 2012