Long‐term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high‐dose intravenous methotrexate | Zendy

Fakhry Carole | Zendy; Bajaj Gopal | Zendy; Aygun Nafi | Zendy; Westra William | Zendy; Gillison Maura | Zendy

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Long‐term survival of a patient with leptomeningeal involvement by nasopharyngeal carcinoma after treatment with high‐dose intravenous methotrexate

Author(s) -

Fakhry Carole,

Bajaj Gopal,

Aygun Nafi,

Westra William,

Gillison Maura

Publication year - 2012

Publication title -

head and neck

Language(s) - English

Resource type - Journals

SCImago Journal Rank - 1.012

H-Index - 127

eISSN - 1097-0347

pISSN - 1043-3074

DOI - 10.1002/hed.21516

Subject(s) - medicine , nasopharyngeal carcinoma , methotrexate , asymptomatic , oncology , carcinoma , surgery , radiation therapy

Background. Nasopharyngeal carcinoma with leptomeningeal involvement is rare and typically has poor prognosis. Methods and Results. We present a case report of a patient with nasopharyngeal carcinoma who was treated with high‐dose intravenous methotrexate and remains asymptomatic and without clinical evidence of disease 6 years later. Conclusions. Systemic high‐dose methotrexate should be evaluated in the treatment of advanced nasopharyngeal carcinoma with central nervous involvement. © 2010 Wiley Periodicals, Inc. Head Neck, 2012

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